MUTAGENICITY TESTS OF TAZOBACTAM/PIPERACILLIN, TAZOBACTAM AND PIPERACILLIN

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Piperacillin/tazobactam Induced Myelosuppression

UNLABELLED Neutropenia, secondary to immune destruction or maturation arrest, is the most commonly described adverse haematological effect of beta-lactam antibiotics. We describe a case of reversible pancytopenia, with evidence of hypocellular marrow, after a prolonged course of piperacillin/tazobactam for 26 days. KEYWORDS Piperacillin; Tazobactam; Myelosuppression; Neutropenia.

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CLINICAL PHARMACOLOGY Adults Peak plasma concentrations of piperacillin and tazobactam are attained immediately after completion of an intravenous infusion of Piperacillin and Tazobactam for Injection. Piperacillin plasma concentrations, following a 30 minute infusion of Piperacillin and Tazobactam for Injection, were similar to those attained when equivalent doses of piperacillin were administ...

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ژورنال

عنوان ژورنال: The Journal of Toxicological Sciences

سال: 1994

ISSN: 0388-1350,1880-3989

DOI: 10.2131/jts.19.supplementii_263